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- Case Report
- DiGeorge syndrome who developed lymphoproliferative mediastinal mass
- Kyu Yeun Kim, Ji Ae Hur, Ki Hwan Kim, Yoon Jin Cha, Mi Jung Lee, Dong Soo Kim
- Clin Exp Pediatr. 2015;58(3):108-111. Published online March 20, 2015
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DiGeorge syndrome is an immunodeficient disease associated with abnormal development of 3rd and 4th pharyngeal pouches. As a hemizygous deletion of chromosome 22q11.2 occurs, various clinical phenotypes are shown with a broad spectrum. Conotruncal cardiac anomalies, hypoplastic thymus, and hypocalcemia are the classic triad of DiGeorge syndrome. As this syndrome is characterized by hypoplastic or aplastic thymus, there are missing...
- Original Article
- Blood culture contamination in hospitalized pediatric patients: a single institution experience
- Hyewon Min, Cheong Soo Park, Dong Soo Kim, Ki Hwan Kim
- Clin Exp Pediatr. 2014;57(4):178-185. Published online April 30, 2014
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Purpose Blood culture is the most important tool for detecting bacteremia in children with fever. However, blood culture contamination rates range from 0.6% to 6.0% in adults; rates for young children have been considered higher than these, although data are limited, especially in Korea. This study determined the contamination rate and risk factors in pediatric patients visiting the emergency room (ER)...
- Enhanced detection and serotyping of
Streptococcus pneumoniae using multiplex polymerase chain reaction - Jong Gyun Ahn, Seong Yeol Choi, Dong Soo Kim, Ki Hwan Kim
- Clin Exp Pediatr. 2012;55(11):424-429. Published online November 23, 2012
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Purpose Methods for quick and reliable detection of
Streptococcus pneumoniae are needed for the diagnosis of pneumococcal disease and vaccine studies. This study aimed to show that sequential multiplex polymerase chain reaction (PCR) is more efficient than conventional culture in achievingS. pneumoniae -positive results.Methods Nasopharyngeal (NP) secretions were obtained from 842 pediatric patients admitted with lower respiratory infections at Severance Children's Hospital...
- Review Article
- Juvenile idiopathic arthritis: Diagnosis and differential diagnosis
- Ki Hwan Kim, Dong Soo Kim
- Clin Exp Pediatr. 2010;53(11):931-935. Published online November 30, 2010
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Juvenile idiopathic arthritis (JIA) is comprised of a heterogeneous group of several disease subtypes that are characterized by the onset of arthritis before the age of 16 years and has symptoms lasting at least 6 weeks. The previous classification of JIA included seven different categories, whereas its current classification was compiled by the International League of the Association for Rheumatology,...
- Case Report
- A case of postoperative nasopharyngeal reflux associated with retropharyngeal lymphangioma in newborn infant
- Ah Reum Kwon, Eun Jung Park, Ki Hwan Kim, Dong Soo Kim
- Clin Exp Pediatr. 2010;53(2):262-266. Published online February 15, 2010
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Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine involved in the pathophysiology of juvenile rheumatoid arthritis. Etanercept is an effective inhibitor of TNF-α and has shown a beneficial effect in patients with JRA. However, the most important cause of concern related to etanercept administration is infection. We report a case of encephalitis in a JRA patient receiving long-term treatment... -
- Original Article
- Nationwide surveillance of acute interstitial pneumonia in Korea
- Byoung-Ju Kim, Han A Kim, Young-Hwa Song, Jinho Yu, Seonguk Kim, Seong Jong Park, Kyung Won Kim, Kyu-Earn Kim, Dong Soo Kim, June Dong Park, Kang Mo Ahn, Hyo-Bin Kim, Hyang-Min Jung, Chun Kang, Soo-Jong Hong
- Clin Exp Pediatr. 2009;52(3):324-329. Published online March 15, 2009
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Purpose : Acute interstitial pneumonia (AIP) is a rare disease, but its prognosis is fatal because of lack of efficient treatment modality. Recently, it has been reported that there was epidemic AIP in Korea. This study aims to investigate the past and current status of AIP in Korea. Methods : We performed a nationwide survey and a prospective study. From August... -
- Comparison of a whole blood Interferon-γ assay and A tuberculin skin test for detecting latent tuberculosis infection in children
- Jin-Kyong Chun, Jin-Kyong Chun, Chang Ki Kim, Chang Ki Kim, Hyun Sook Kim, Hyun Sook Kim, Ghee Young Jung, Ghee Young Jung, John A. Linton, John A. Linton, Ki Hwan Kim, Ki Hwan Kim, Taek Jin Lee, Taek Jin Lee, Ji Hyun Jeon, Ji Hyun Jeon, Dong Soo Kim, Dong Soo Kim
- Clin Exp Pediatr. 2008;51(9):971-976. Published online September 15, 2008
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Purpose : Surveillance for detecting and managing latent tuberculosis infection (LTBI) is a key component of tuberculosis control. The classic surveillance tool, the tuberculin skin test (TST), may have some limitations when used in the Bacillus Calmette-Guérin (BCG)-vaccinated population. The object was to perform a blood test QuantiFERON®-TB Gold In Tube (QFT-G IT) based on the detection of interferon-γ (IFN-γ)... -
- Clinical characteristics and prognostic factors for survival in hemophagocytic lymphohistiocytosis
- Khi Joo Kim, Ki Hwan Kim, Taek Jin Lee, Jin-Kyong Chun, Chuhl Joo Lyu, Dong Soo Kim
- Clin Exp Pediatr. 2008;51(3):299-306. Published online March 15, 2008
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Purpose : Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by fever, splenomegaly, pancytopenia, and hemophagocytosis in the bone marrow and other tissues. In this study, we investigated the clinical manifestations and prognostic factors in patients with HLH. Methods : We retrospectively analyzed the data from 29 patients who were diagnosed whit HLH in the Severance Children's Hospital from... -
- Review Article
- Juvenile rheumatoid arthritis
- Dong Soo Kim
- Clin Exp Pediatr. 2007;50(12):1173-1179. Published online December 15, 2007
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The diagnosis of juvenile rheumatoid arthritis (JRA) is based on patient's age at disease onset, symptom duration, gender, and clinical manifestations. JRA is of unknown origin, begins under the age of 16, and persists for a minimum of 6 weeks. JRA is categorized into three principal types, systemic, oligoarticular and polyarticular. Infection, other connective tissue diseases, malignancy, trauma, and immunodeficiency... -
- Fever
- Taek Jin Lee, Dong Soo Kim
- Clin Exp Pediatr. 2007;50(2):121-126. Published online February 15, 2007
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Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes... -
- Original Article
- A clinical study of systemic lupus erythematosus in children
- Ji Tae Kim, Young Mee Nam, Jae Seung Lee, Dong Soo Kim
- Clin Exp Pediatr. 2007;50(1):74-78. Published online January 15, 2007
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Purpose : Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE. Methods : The data of 45 patients who were diagnosed as pediatric SLE in Severance... -
- Epidemiology of central venous catheter related blood stream infections in pediatric patients
- Jung Hyun Kim, Ho Sun Eun, Kyung Min Choi, Dong Soo Kim, Dong Eun Young
- Clin Exp Pediatr. 2006;49(2):157-161. Published online February 15, 2006
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Purpose : The purpose of this study is to investigate the pathogens of central venous catheter-related blood stream infections and search for the association among the insertion site, the duration and the underlying conditions with the prevalence of central venous catheter-related blood stream infections under 15 years old. Methods : A retrospective study was performed from Jan, 2003 to Dec, 2003... -
- Statistical Analysis of 1,000 Cases of Kawasaki Disease Patients Diagnosed at a Single Institute
- Dae Hwan Hwang, Kyoung Mi Sin, Kyong Min Choi, Jae Young Choi, Jun Hee Sul, Dong Soo Kim
- Clin Exp Pediatr. 2005;48(4):416-424. Published online April 15, 2005
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Purpose : To find the risk factors associated with coronory artery lesions, non-responsiveness to intravenous immunoglobulin(IVIG) treatment, and recurrences in Kawasaki disease patients. Methods : We retrospectively analyzed 1,000 Kawasaki disease patients who were admitted to Yonsei University Medical Center from September 1990 to December 2003. We compared between responder and non-responder groups to IVIG treatment as well as between relapsed... -
- Case Report
- A Case of Multiple Giant Coronary Aneurysms with Large Mural Thrombus due to Kawasaki Disease in a Young Infant
- Eun Na Choi, Jeoung Tae Kim, Yuria Kim, Byung Won Yoo, Deok Young Choi, Jae Young Choi, Jun Hee Sul, Sung Kye Lee, Dong Soo Kim, Young Hwan Park
- Clin Exp Pediatr. 2005;48(3):321-326. Published online March 15, 2005
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Kawasaki disease is an acute systemic vasculitis of unknown origin. Giant coronary aneurysm is one of the most serious complications, although peripheral artery vasculitis can produce life-threatening events. Myocardial ischemia and infarction can be caused by coronary artery stenosis, aneurysm, and stagnation of blood flow in coronary arteries which triggers thromboembolism. Atypical presentation in young infants often interferes with prompt... -
- Original Article
- Expression of Toll-like Receptor-2 on the Peripheral Blood Monocytes in Kawasaki Disease Patients
- Dae Hwan Hwang, Jung Woo Han, Kyung Min Choi, Kyung Mi Shin, Dong Soo Kim
- Clin Exp Pediatr. 2005;48(3):315-320. Published online March 15, 2005
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Objective : Toll like receptor(TLR) is known to be involved in innate immunity. Many microbial antigens stimulate TLR, and as a result of intracellular signal transduction, they activate nuclear factor-kB which produces diverse inflammtory cytokines. Until now, many research topics in Kawasaki disease focused on cytokine increasement. In this study, we aim to reveal TLR increasement which might be associated... -
- Effect of Histone H1 on Collagen Induced Arthritis in Mice
- Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
- Clin Exp Pediatr. 2004;47(7):779-788. Published online July 15, 2004
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Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,... -
- Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice
- Kyong Min Choi, Dae Hwan Hwang, Kyung Mi Shin, Do-Young Yoon, Dong Soo Kim
- Clin Exp Pediatr. 2004;47(6):677-684. Published online June 15, 2004
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Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies... -
- Comparison of Serum Proteome Maps of Children with Kawasaki Disease
- Seoung Yon Baek, Young-Mock Lee, Kwang Hoon Lee, Dong Soo Kim
- Clin Exp Pediatr. 2004;47(1):81-89. Published online January 15, 2004
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Purpose : Kawasaki disease is a systemic vasculitis observed in children under five years of age and the leading cause of pediatric acquired heart disease, but its pathophysiology is still not completely understood. With proteomics, the study of quality and quantity of proteins, having been developed dramatically, we tried to find a way to evaluate the etiology and pathogenesis of... -
- Characterization of B Cells of Lymph Nodes and Peripheral Blood in a Patient with Hyper IgM Syndrome
- Dong Soo Kim, Kyuong Mi Shin, Woo Ick Yang, Jeon-Soo Shin, Chang Hwa Song, Eun Kyeong Jo
- Clin Exp Pediatr. 2003;46(2):128-136. Published online February 15, 2003
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Purpose : Hyper IgM syndrome(HIGM) is characterized by severe recurrent bacterial infections with decreased serum levels of IgG, IgA, and IgE but elevated IgM levels. Recently, it has been classified into three groups; HIGM1, HIGM2 and a rare form of HIGM. HIGM1 is a X-linked form of HIGM and has now been identified as a T-cell deficiency in which mutations... -
- A Clinical Study of the Acute Respiratory Distress Syndrome in Children
- Taek Jin, Dong Soo Kim, Dong Hwan Shin
- Clin Exp Pediatr. 2003;46(1):42-50. Published online January 15, 2003
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Purpose : The acute respiratory distress syndrome(ARDS), an acute form of severe alveolar-capillary injury evolving after a direct or indirect lung insult is thought to be a common cause of respiratory failure though not many clinical studies on the subject have been made yet. Methods : Between January 1992 and December 2001, we conducted a retrospective study on 33 children who... -
- Case Report
- A Case of Polyarteritis Nodosa in Childhood
- Jung Ho Seo, Dong Soo Kim, Myung Joon Kim
- Clin Exp Pediatr. 2001;44(4):456-459. Published online April 15, 2001
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Polyarteritis nodosa(PAN) is a multisystemic disease primarily involving the small and medium- sized vessels. Prognosis depends on the presence and severity of visceral involvement. Gastrointestinal involvement in PAN may result in vague abdominal pain, nausea and melena. Angiography can be used to establish a diagnosis of PAN. We report a case of polyarteritis nodosa presenting with recurrent abdominal pain, melena... -
- Original Article
- Treatment Outcome of Penicillin-resistant S. Pneumoniae Infection
- Min Sook Choi, Young Won Kim, Dong Soo Kim, Kyung Won Lee
- Clin Exp Pediatr. 2001;44(2):149-153. Published online February 15, 2001
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Purpose : Streptococcus pneumoniae is a normal flora and common pathogen of the upper respiratory tract. S. pneumoniae infections are estimated to cause not only localized infection such as pneumonia, and otitis media, but also systemic infections, for example meningitis, sepsis, and so on. Recently, the resistance of S. pneumoniae to penicillin and multidrug has been rapidly increasing in many... -
- Apoptosis of Peripheral Blood Mononuclear Cells in Different Ages of Normal Children
- Dong Soo Kim, Hyun Young Kim, John A Linton
- Clin Exp Pediatr. 2000;43(4):463-469. Published online April 15, 2000
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Purpose : To survive in an ecological environment, an individual must develop immunity to various antigens. Therefore, populations of peripheral blood mononuclear cells(PBMC) in humans change continuously with growth. The object of this study is to evaluate the apoptosis of peripheral blood mononuclear cells(PBMC) in normal children of different ages. Methods : PBMC were isolated from the study groups. Ten... -
- Apoptosis of Cord Blood Mononuclear Cells Infected with Enterovirus
- Dong Soo Kim
- Clin Exp Pediatr. 2000;43(3):372-379. Published online March 15, 2000
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Purpose : To evaluate apoptosis of cord blood mononuclear cells(CBMC) infected with enterovirus. Methods : Cord blood was obtained from 20 neonates which were delivered vaginally without any complications. Cord blood mononuclear cells(CBMC) were isolated, and after 24h and 48h incubation, cells were stained with Annexin V and Propidium Iodide and were analyzed with FACScan flowcytometer. CBMCs were also incubated with... -
- Prevalence and Identification of Rotaviruses in Stool Specimens of Patients with Acute Diarrhea from Several Regions of Korea
- Dong Soo Kim, Beom Soo Park, Dong Hyuk Jung, Jae Moon Ahn, Chul Joong Kim, Shien Young Kang
- Clin Exp Pediatr. 1999;42(4):501-509. Published online April 15, 1999
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Purposes : Rotaviruses are the main cause of infantile diarrheal diseases worldwide. The purpose of this study is to obtain epidemiologic data of rotavirus infections in Korea. Methods : Stool specimens were collected from 150 patients with acute diarrheal symptoms, who were admitted to Yonsei Medical Center and Chungbuk National University Hospital. After isolating the virus from the specimens, the viruses... -
- The Effect of Acanthopanax koreanum Extract on the Induction of Collagen Induced Arthritis for DBA/1J Mice
- Dong Soo Kim, Chang Ho Song, Soo Kon Lee
- Clin Exp Pediatr. 1998;41(2):247-254. Published online February 15, 1998
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Purpose : It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study to see whether the Acanthopanax koreanum extract has a preventive effect on the development of collagen induced arthritis in DBA/1J mice. Methods : Three groups of BDA/1J mice were immunized by intradermal injection of 2mg/kg bovine type... -
- Case Report
- A Case of Kawasaki Disease of Five Recurrences During 4 Years
- Jeong Woo Ryu, Dong Soo Kim, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee
- Clin Exp Pediatr. 1997;40(9):1293-1296. Published online September 15, 1997
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Kawasaki disease is an acute illness of early childhood, especially less than 5 years of age, characterized by prolonged fever(> 5 days), changes of lips and oral cavity, changes of peripheral extremities, polymorphous skin rash, bilateral conjunctival congestion and acute nonpurulent cervical lymphadenopathy. Usually, the recurrence of Kawasaki disease is not frequent. It is thought that the factors in recurrence of Kawasaki disease was... -
- Original Article
- Clinical Investigation of Neck Masses in Children
- Sung Chul Byun, Dong Soo Kim
- Clin Exp Pediatr. 1996;39(10):1429-1442. Published online October 15, 1996
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Purpose : Neck masses are frequently encountered in pediatric practice, and have various underlying diseases. If the underlying diseases of the neck mass are not confirmed by its clinical characteristics, it can be done by neck mass biopsy. To define the necessity and the appropriate time of neck mass biopsy is very difficult and also important. Therefore the authers have conducted this study to... -
- Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis
- Moon Kyu Kim, Dong Soo Kim
- Clin Exp Pediatr. 1995;38(5):625-632. Published online May 15, 1995
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Purpose : Aseptic meningitis is an infection of CNS caused by virus and there are remarka-ble changes in endogenous cytokine level. Interleukin-6 is a pleiotropic and multi-functional cyt-okine and plays a central role in host defense mechanisms. We studied the IL--6 level in serum and CSF with the patients of aseptic meningitis and investigated the relationship of IL-6 with C... -
- House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA
- Ji Hong Kim, Soo Young Lee, Byeung Ju Jeung, Kye Earn Kim, Dong Soo Kim, Ki Young Lee
- Clin Exp Pediatr. 1994;37(12):1701-1708. Published online December 15, 1994
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House dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssius, have been identified as the main sources of house dust allergen and are considersed the most important causative allergen in the etiology of allergic respiaratory disease and allergic rhinitis. To evaluate the incidence of positive skin reactivity to house dust mites and relationship between total serum IgE levels and specific IgE antibody to... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
